MOG-IgG positive optic neuritis after SARS-CoV-2 infection

Gilardi M, Cortese A, Ferraro E, Rispoli M, Sadun R, Altavista MC, Sadun F.
Eur J Ophthalmol. 2022 Nov 1:11206721221136319. doi: 10.1177/11206721221136319. Online ahead of print.
PMID: 36317310 Free PMC article.
Publication year: 2022
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Abstract

Background: Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG.

Objective: To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger.

Methods: Retrospective single case report.

Results: We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection.

Conclusion: This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.

Keywords: immunology < IMMUNOLOGY; infections disease/aids < NEURO OPHTHALMOLOGY; neuro imaging < NEURO OPHTHALMOLOGY; optic neuritis < NEURO OPHTHALMOLOGY; optic neuropathy < NEURO OPHTHALMOLOGY.